JOCAVIOのコア技術

免疫刺激性遺伝子を導入し、続発性抗腫瘍免疫を誘導

Genetic engineering with a unique combination of immuno-stimulatory genes in a virus with high payload and cell entry efficiency Robust cytotoxicity and sustained host immune responses.

全身反復投与の実現

ウイルスをヒト由来細胞膜でコーティング。
静脈内投与後の抗腫瘍効果の減弱を回避

Systemic administration

Proprietary coating technology to evade host immune responses including autoantibody and recruitment of immune cells. Enabling repeated iv administration.

ペプチド、ナノ抗体等で癌細胞特異性を付与。
Off-target効果を最小化

An unique peptide and exploration of 2-3kD bispecific nanobody for cancer cell targeting to optimize tissue delivery Achieve cancer cell selectivity and minimize off-target effects.

安全性・汎用性向上

ウイルス増殖および遺伝子発現の暴走を体外光照射で制御（スイッチ・オフ）

Controlled gene transduction/viral replication

Light-activated “Magnet” switch to modulate gene transduction and viral replication Mitigate virus-induced or recombinant genes-related adverse events